Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …
endemic regions, where water availability limits mosquito vectors to only part of the year …
Transcriptomic studies of malaria: a paradigm for investigation of systemic host-pathogen interactions
Transcriptomics, the analysis of genome-wide RNA expression, is a common approach to
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …
investigate host and pathogen processes in infectious diseases. Technical and bioinformatic …
The role of PfEMP1 as targets of naturally acquired immunity to childhood malaria: prospects for a vaccine
PC Bull, AI Abdi - Parasitology, 2016 - cambridge.org
The Plasmodium falciparum erythrocyte membrane protein 1 antigens that are inserted onto
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …
the surface of P. falciparum infected erythrocytes play a key role both in the pathology of …
[HTML][HTML] Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq
Background Plasmodium parasites undergo several major developmental transitions during
their complex lifecycle, which are enabled by precisely ordered gene expression programs …
their complex lifecycle, which are enabled by precisely ordered gene expression programs …
[HTML][HTML] The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen …
Within the human host, the malaria parasite Plasmodium falciparum is exposed to multiple
selection pressures. The host environment changes dramatically in severe malaria, but the …
selection pressures. The host environment changes dramatically in severe malaria, but the …
[HTML][HTML] Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes
R Thomson-Luque, L Votborg-Novél, W Ndovie… - Nature …, 2021 - nature.com
Following Plasmodium falciparum infection, individuals can remain asymptomatic, present
with mild fever in uncomplicated malaria cases, or show one or more severe malaria …
with mild fever in uncomplicated malaria cases, or show one or more severe malaria …
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo …
C Andradi-Brown, JS Wichers-Misterek, H von Thien… - Elife, 2024 - elifesciences.org
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …
[HTML][HTML] Understanding P. falciparum asymptomatic infections: a proposition for a transcriptomic approach
Malaria is still a significant public health burden in the tropics. Infection with malaria causing
parasites results in a wide range of clinical disease presentations, from severe to …
parasites results in a wide range of clinical disease presentations, from severe to …
[HTML][HTML] Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections
Virulence of the most deadly malaria parasite Plasmodium falciparum is linked to the variant
surface antigen Pf EMP1, which is encoded by about 60 var genes per parasite genome …
surface antigen Pf EMP1, which is encoded by about 60 var genes per parasite genome …
[HTML][HTML] Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression
The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen
Pf EMP1, which mediates tethering of infected erythrocytes to the host endothelium and is …
Pf EMP1, which mediates tethering of infected erythrocytes to the host endothelium and is …