[HTML][HTML] Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application
K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …
cell biology and special cell mechanisms. The most popular models of cell culture are two …
[HTML][HTML] In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
S Sabate‐Soler, SL Nickels, C Saraiva, E Berger… - Glia, 2022 - Wiley Online Library
The human brain is a complex, three‐dimensional structure. To better recapitulate brain
complexity, recent efforts have focused on the development of human‐specific midbrain …
complexity, recent efforts have focused on the development of human‐specific midbrain …
[HTML][HTML] Modeling Parkinson's disease in midbrain-like organoids
LM Smits, L Reinhardt, P Reinhardt, M Glatza… - NPJ Parkinson's …, 2019 - nature.com
Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a
powerful tool to study disease mechanisms and to elucidate unexplored aspects of this …
powerful tool to study disease mechanisms and to elucidate unexplored aspects of this …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
[HTML][HTML] Mechanical stimulation: a crucial element of organ-on-chip models
CL Thompson, S Fu, HK Heywood… - … in bioengineering and …, 2020 - frontiersin.org
Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …
[HTML][HTML] Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease
K Zhang, S Zhu, J Li, T Jiang, L Feng, J Pei… - … Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …
diseases, is a serious threat to the health of the elderly. The current treatment has been …
Advances in microfluidic in vitro systems for neurological disease modeling
PM Holloway, S Willaime‐Morawek… - Journal of …, 2021 - Wiley Online Library
Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …
death worldwide. Despite significant research efforts, neurology remains one of the most …
Parkinson's disease phenotypes in patient neuronal cultures and brain organoids improved by 2‐Hydroxypropyl‐β‐Cyclodextrin treatment
ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially
understood despite the fact that environmental causes, risk factors, and specific gene …
understood despite the fact that environmental causes, risk factors, and specific gene …
Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research
The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …