Progress in toxicogenomics to protect human health

MJ Meier, J Harrill, K Johnson, RS Thomas… - Nature Reviews …, 2024 - nature.com
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …

Genetic and epigenetic alterations induced by pesticide exposure: integrated analysis of gene expression, microRNA expression, and DNA methylation datasets

F Giambò, GM Leone, G Gattuso, R Rizzo… - International journal of …, 2021 - mdpi.com
Environmental or occupational exposure to pesticides is considered one of the main risk
factors for the development of various diseases. Behind the development of pesticide …

[HTML][HTML] A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy

X Wang, LM Wong, ME McElvain, S Martire… - Toxicology and Applied …, 2022 - Elsevier
Cell therapy is an emerging therapeutic modality with the power to exploit new cancer
targets and potentially achieve positive outcomes for patients with few other options. Like all …

Effects of pesticide exposure on the expression of selected genes in normal and cancer samples: Identification of predictive biomarkers for risk assessment

S Italia, S Vivarelli, M Teodoro, C Costa… - Environmental …, 2024 - Elsevier
Pesticides pivotal in controlling pests, can represent a threat for human health. Regulatory
agencies constantly monitor their harmful effects, regulating their use. Several studies …

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

P Chen, Y Li, Q Long, T Zuo, Z Zhang, J Guo, D Xu, K Li… - Chemosphere, 2023 - Elsevier
Next-generation risk assessment (NGRA) for environmental chemicals involves a weight of
evidence (WoE) framework integrating a suite of new approach methodologies (NAMs) …

T1000: a reduced gene set prioritized for toxicogenomic studies

O Soufan, J Ewald, C Viau, D Crump, M Hecker… - PeerJ, 2019 - peerj.com
There is growing interest within regulatory agencies and toxicological research communities
to develop, test, and apply new approaches, such as toxicogenomics, to more efficiently …

A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration …

L Fresnais, O Perin, A Riu, R Grall, A Ott, B Fromenty… - BMC …, 2024 - Springer
Background The growing abundance of in vitro omics data, coupled with the necessity to
reduce animal testing in the safety assessment of chemical compounds and even eliminate …

A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration …

L Fresnais, O Perin, A Riu, R Grall, A Ott, B Fromenty… - 2024 - hal.science
Background: The growing abundance of in vitro omics data, coupled with the necessity to
reduce animal testing in the safety assessment of chemical compounds and even eliminate …