Progress in toxicogenomics to protect human health
Toxicogenomics measures molecular features, such as transcripts, proteins, metabolites and
epigenomic modifications, to understand and predict the toxicological effects of …
epigenomic modifications, to understand and predict the toxicological effects of …
Genetic and epigenetic alterations induced by pesticide exposure: integrated analysis of gene expression, microRNA expression, and DNA methylation datasets
Environmental or occupational exposure to pesticides is considered one of the main risk
factors for the development of various diseases. Behind the development of pesticide …
factors for the development of various diseases. Behind the development of pesticide …
[HTML][HTML] A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapy
X Wang, LM Wong, ME McElvain, S Martire… - Toxicology and Applied …, 2022 - Elsevier
Cell therapy is an emerging therapeutic modality with the power to exploit new cancer
targets and potentially achieve positive outcomes for patients with few other options. Like all …
targets and potentially achieve positive outcomes for patients with few other options. Like all …
Effects of pesticide exposure on the expression of selected genes in normal and cancer samples: Identification of predictive biomarkers for risk assessment
S Italia, S Vivarelli, M Teodoro, C Costa… - Environmental …, 2024 - Elsevier
Pesticides pivotal in controlling pests, can represent a threat for human health. Regulatory
agencies constantly monitor their harmful effects, regulating their use. Several studies …
agencies constantly monitor their harmful effects, regulating their use. Several studies …
The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration
P Chen, Y Li, Q Long, T Zuo, Z Zhang, J Guo, D Xu, K Li… - Chemosphere, 2023 - Elsevier
Next-generation risk assessment (NGRA) for environmental chemicals involves a weight of
evidence (WoE) framework integrating a suite of new approach methodologies (NAMs) …
evidence (WoE) framework integrating a suite of new approach methodologies (NAMs) …
T1000: a reduced gene set prioritized for toxicogenomic studies
There is growing interest within regulatory agencies and toxicological research communities
to develop, test, and apply new approaches, such as toxicogenomics, to more efficiently …
to develop, test, and apply new approaches, such as toxicogenomics, to more efficiently …
A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration …
L Fresnais, O Perin, A Riu, R Grall, A Ott, B Fromenty… - BMC …, 2024 - Springer
Background The growing abundance of in vitro omics data, coupled with the necessity to
reduce animal testing in the safety assessment of chemical compounds and even eliminate …
reduce animal testing in the safety assessment of chemical compounds and even eliminate …
A strategy to detect metabolic changes induced by exposure to chemicals from large sets of condition-specific metabolic models computed with enumeration …
L Fresnais, O Perin, A Riu, R Grall, A Ott, B Fromenty… - 2024 - hal.science
Background: The growing abundance of in vitro omics data, coupled with the necessity to
reduce animal testing in the safety assessment of chemical compounds and even eliminate …
reduce animal testing in the safety assessment of chemical compounds and even eliminate …