In the past decades, numerous preclinical studies and several clinical trials have evidenced
the feasibility of cell transplantation in treating heart diseases. Over the years, different …

Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

After a myocardial infarction, heart tissue becomes irreversibly damaged, leading to scar
formation and inevitably ischemic heart failure. Of the many available interventions after a …

Although cell therapy has shown potential efficacy in the treatment of heart diseases, one
challenge is low cellular retention rate and poor engraftment. We sought to perform a head …

Pigs have traditionally been used for preclinical experiments, and body size-matching is
important for cell therapy in animal models used for preclinical trials. It has been shown that …

The remote but heart-encircling location of pericardial fluid confers this biofluid unique
properties. Once past the limitation of the invasive collection, for instance, on occasion of …

Acute myocardial infarction triggers a strong inflammatory response in the affected cardiac
tissue. New therapeutic tools based on stem cell therapy may modulate the unbalanced …

Background Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression
could provide an effective ancillary therapy to improve cardiac function in reperfused …

Background Bone-derived mesenchymal stem cell (BMSC) transplantation has been
reported to be effective for the treatment of ischemic heart disease, but whether BMSCs are …

The pericardium is a double-layered fibro-serous sac that envelops the majority of the
surface of the heart as well as the great vessels. Pericardial fluid is also contained within the …