Global Cancer Statistics 2022: the trends projection analysis

BS Chhikara, K Parang - Chemical Biology Letters, 2023 - pubs.thesciencein.org
Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

A gold mine for drug discovery: Strategies to develop cyclic peptides into therapies

X Jing, K Jin - Medicinal research reviews, 2020 - Wiley Online Library
As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

Cyclic cell-penetrating peptides as efficient intracellular drug delivery tools

SE Park, MI Sajid, K Parang, RK Tiwari - Molecular pharmaceutics, 2019 - ACS Publications
Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge
potential for the intracellular delivery of therapeutic agents aimed at treating challenging …

The recent advance of cell-penetrating and tumor-targeting peptides as drug delivery systems based on tumor microenvironment

Q Zhang, N Liu, J Wang, Y Liu, K Wang… - Molecular …, 2023 - ACS Publications
Cancer has become the primary reason for industrial countries death. Although first-line
treatments have achieved remarkable results in inhibiting tumors, they could have serious …

Cell penetrating peptides: classification, mechanisms, methods of study, and applications

A Gori, G Lodigiani, SG Colombarolli… - …, 2023 - Wiley Online Library
Cell‐penetrating peptides (CPPs) encompass a class of peptides that possess the
remarkable ability to cross cell membranes and deliver various types of cargoes, including …

Tryptophan, more than just an interfacial amino acid in the membrane activity of cationic cell-penetrating and antimicrobial peptides

S Khemaissa, A Walrant, S Sagan - Quarterly Reviews of Biophysics, 2022 - cambridge.org
Trp is unique among the amino acids since it is involved in many different types of
noncovalent interactions such as electrostatic and hydrophobic ones, but also in π-π, π …

[HTML][HTML] How cargo identity alters the uptake of cell-penetrating peptide (CPP)/Cargo complexes: A study on the effect of net cargo charge and length

HC Hymel, A Rahnama, OM Sanchez, D Liu… - Cells, 2022 - mdpi.com
Cell-penetrating peptides (CPPs) have emerged as a powerful tool for the delivery of
otherwise impermeable cargoes into intact cells. Recent efforts to improve the delivery …

[HTML][HTML] Amphiphilic cell-penetrating peptides containing natural and unnatural amino acids as drug delivery agents

D Salehi, S Mozaffari, K Zoghebi, S Lohan, D Mandal… - Cells, 2022 - mdpi.com
A series of cyclic peptides,[(DipR)(WR) 4],[(DipR) 2 (WR) 3],[(DipR) 3 (WR) 2],[(DipR) 4
(WR)], and [DipR] 5, and their linear counterparts containing arginine (R) as positively …

Cyclic and linear peptides containing alternate WW and RR residues as molecular cargo delivery tools

L Kim, S Lohan, J Moreno, K Zoghebi… - Molecular …, 2022 - ACS Publications
Cell-impermeable and negatively charged compounds' cellular uptake across the cell
membranes remains challenging. Herein, the synthesis of four linear [(WWRR) 2,(WWRR) …

Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool

MI Sajid, M Moazzam, R Stueber, SE Park, Y Cho… - Peptides, 2021 - Elsevier
A new class of peptides, cyclic cell-penetrating peptides (CPPs), has great potential for
delivering a vast variety of therapeutics intracellularly for treating diverse ailments. CPPs …