Mechanosensing in macrophages and dendritic cells in steady-state and disease

M Lee, H Du, DA Winer… - Frontiers in cell and …, 2022 - frontiersin.org
Macrophages and dendritic cells are myeloid cells that play critical roles in immune
responses. Macrophages help to maintain homeostasis through tissue regeneration and the …

Crosstalk between macrophages and cardiac cells after myocardial infarction

Y Jian, X Zhou, W Shan, C Chen, W Ge, J Cui… - Cell Communication and …, 2023 - Springer
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death
worldwide. Acute MI (AMI) inflicts massive injury to the coronary microcirculation, causing …

Potential diagnostic biomarkers: 6 cuproptosis-and ferroptosis-related genes linking immune infiltration in acute myocardial infarction

M Miao, S Cao, Y Tian, D Liu, L Chen, Q Chai… - Genes & …, 2023 - nature.com
The current diagnostic biomarkers of acute myocardial infarction (AMI), troponins, lack
specificity and exist as false positives in other non-cardiac diseases. Previous studies …

CNP ameliorates macrophage inflammatory response and atherosclerosis

Q Bao, B Zhang, L Zhou, Q Yang, X Mu, X Liu… - Circulation …, 2024 - Am Heart Assoc
BACKGROUND: CNP (C-type natriuretic peptide), an endogenous short peptide in the
natriuretic peptide family, has emerged as an important regulator to govern vascular …

MST1: a future novel target for cardiac diseases

Y Shao, Y Wang, L Sun, S Zhou, J Xu, D Xing - International Journal of …, 2023 - Elsevier
Major heart diseases pose a serious threat to human health. Finding early diagnostic
markers and key therapeutic targets is an urgent scientific problem in this field. Mammalian …

A cardioimmunologist's toolkit: genetic tools to dissect immune cells in cardiac disease

A Wong, H Hamidzada, S Epelman - Nature Reviews Cardiology, 2022 - nature.com
Cardioimmunology is a field that encompasses the immune cells and pathways that
modulate cardiac function in homeostasis and regulate the temporal balance between tissue …

MST1 suppresses disturbed flow induced atherosclerosis

M Quan, H Lv, Z Liu, K Li, C Zhang, L Shi… - Circulation …, 2022 - Am Heart Assoc
Background: Atherosclerosis occurs mainly at arterial branching points exposed to disturbed
blood flow. How MST1 (mammalian sterile 20-like kinase 1), the primary kinase in the …

Endothelial YAP mediates hyperglycemia-induced platelet hyperactivity and arterial thrombosis

Z Li, J Zhang, Z Ma, G Zhao, X He, X Yu… - … and Vascular Biology, 2024 - Am Heart Assoc
BACKGROUND: Hyperglycemia—a symptom that characterizes diabetes—is highly
associated with atherothrombotic complications. However, the underlying mechanism by …

Regulatory mechanism of macrophage polarization based on Hippo pathway

Y Liu, Y An, G Li, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
Macrophages are found to infiltrate and migrate in a large number of Tumor-associated
macrophages (TMEs) and other macrophages in the microenvironment of tumors and …

[HTML][HTML] Serine/threonine kinase 3 promotes oxidative stress and mitochondrial damage in septic cardiomyopathy through inducing Kelch-like ECH-associated protein …

H Zhu, Z Dai, X Liu, H Zhou, Y Wang - International Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Serine/threonine kinases (STK3) is a core component of the Hippo pathway and
modulates oxidative stress and inflammatory responses in cardiovascular diseases …