This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Amanzio and Benedetti (J Neurosci 1999; 19: 484—494) first addressed the conditions
necessary for the activation of opioid and non-opioid placebo responses in human. Here, we …

To examine possible blood–brain barrier (BBB) transport interactions between oxycodone
and adjuvant analgesics, we firstly screened various candidates in vitro using [3 H] …

We present in this article syntheses of six new hybrids compounds (4–9) that were efficiently
prepared in one or two steps (70–84.6%) from our previous prototype (±)-cis-4-chloro-6 …

In this paper we present the convenient syntheses of six new guanylhydrazone and
aminoguanidine tetrahydropyran derivatives 2–7. The guanylhydrazone 2, 3 and 4 were …

Aims There has been growing interest in the synthesis of new derivatives from isatin, found
in Isatis genus. Our objectives were to characterize the antinociceptive mechanism of action …

We described in this article the very efficient 2, 6-cis ou 2, 4, 6-cis diastereoselective
synthesis (2 or 3 steps, 62–65% global yields) from Prins-cyclization reaction as synthetic …

Pain is responsible for inducing physical and mental stress, interfering negatively in patients'
quality of life. Classic analgesic drugs, such as opioids and non‐steroidal anti‐inflammatory …

The present study used behavioral analyses to investigate the involvement of the
NO/cGMP/KATP pathway, serotoninergic, and opioid systems in the antinociceptive action of …

The diastereoselective synthesis of (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one, as
a mixture trans: cis (3: 1), was accomplished using a protocol that combine the Prins …