The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …

The culture of bone marrow derived mesenchymal stem cells (MSCs), as well as the control
of its differentiation toward different tissue lineage, is a very important part of tissue …

In this study, silk fibroin and hyaluronic acid (HA) were enzymatically crosslinked to form
biocompatible composite hydrogels with tunable mechanical properties similar to that of …

As dense connective tissues connecting bone to muscle and bone to bone, respectively,
tendon and ligament (T/L) arise from the somitic mesoderm, originating in a recently …

Elastomeric, fully degradable, and biocompatible biomaterials are rare, with current options
presenting significant limitations in terms of ease of functionalization and tunable …

Tendon injuries are a global health problem that affects millions of people annually. The
properties of tendons make their natural rehabilitation a very complex and long-lasting …

Silk from the silkworm, Bombyx mori, has been used as biomedical suture material for
centuries. The unique mechanical properties of these fibers provided important clinical …

Two important goals in stem cell research are to control the cell proliferation without
differentiation and to direct the differentiation into a specific cell lineage when desired. Here …

Ex vivo engineering of living tissues is a rapidly developing area with the potential to impact
significantly on a wide-range of biomedical applications. Major obstacles to the generation …