Zebrafish is an established model for the study of vertebrate development, and is especially
amenable for investigating hematopoiesis, where there is strong conservation of key …

Abstract ETV6 (TEL1) and ETV7 (TEL2) are closely-related members of the ETS family of
transcriptional regulators. Both ETV6 and ETV7 have been demonstrated to play key roles in …

Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of
these patients have monoallelic germline mutations in ETV6 or RUNX1 and a heightened …

Chromosomal translocations in cancer as well as benign neoplasias typically lead to the
formation of fusion genes. Such genes may encode chimeric proteins when two protein …

Background Tumor metastasis is one of the main causes of the high mortality of
hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong …

Recurrent gene rearrangements result in gene fusions that encode chimeric proteins, driving
the pathogenesis of many hematologic neoplasms. The fifth edition World Health …

Background/Aim: New chromosomal aberrations continue to be reported in acute myeloid
leukemias (AML). The addition of more cases with the same genetic characteristics would …

At present, survivin is one of the most cancer-specific proteins that has been identified. The
present study aimed to investigate the antitumor effects of novel survivin small interfering …

Background Acquired primary chromosomal changes in cancer are sometimes found as
sole karyotypic abnormalities. They are specifically associated with particular types of …

RNA-sequencing of the patient's bone marrow detected fusion transcripts in which the
coding sequence of the FAM53B gene (from 10q26) was fused to a genomic sequence (from …