Simple Summary Chimeric antigen receptor (CAR)-T and-natural killer (NK) therapies are
promising in cancer treatment. CAR-NK therapy gains great attention due to the lack of …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the potential
to differentiate into various types of cells including skeletal muscle cells. The approach of …

Rationale: Hereditary pulmonary alveolar proteinosis (hPAP) caused by granulocyte–
macrophage colony–stimulating factor (GM-CSF) receptor α-chain (CSF2RA) deficiency is a …

Epigenetic silencing of transgene expression represents a major obstacle for the efficient
genetic modification of multipotent and pluripotent stem cells. We and others have …

Background The native articular cartilage lacks the ability to heal. Currently, ex vivo
expanded chondrocytes or bone marrow-derived mesenchymal stem cells are used to …

The domestic pig is an important large animal model for preclinical testing of novel cell
therapies. Recently, we produced pluripotency reporter pigs in which the Oct4 promoter …

Kidney diseases are a prevalent health problem around the world. Multidrug therapy used in
the current routine treatment for kidney diseases can only delay disease progression. None …

Methylation-induced gene silencing represents a major obstacle to efficient transgene
expression in pluripotent cells and thereof derived tissues. As ubiquitous chromatin opening …

Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly
attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal …

Hematopoietic stem cells (HSC) represent the prototype stem cell within the body. Since
their discovery, HSC have been the focus of intensive research, and have proven invaluable …