Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase
(PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important …

Colorectal cancer (CRC) represents the third most commonly diagnosed cancer and the
second leading cause of cancer death worldwide. The modern concept of cancer biology …

Background Ovarian cancer (OV) is the most lethal gynecological cancer in women. We aim
to develop a generalized, individualized immune prognostic signature that can stratify and …

Metformin is a standard clinical drug used to treat type 2 diabetes mellitus (T2DM) and
polycystic ovary syndrome. Recently, epidemiological studies and meta‑analyses have …

Background: We examined the potential of metformin (MET) to enhance non-small cell lung
cancer (NSCLC) responses to ionising radiation (IR). Methods: Human NSCLC cells, mouse …

The biguanide metformin, a widely used drug for the treatment of type 2 diabetes, may exert
cancer chemopreventive effects by suppressing the transformative and hyperproliferative …

Metformin, a first line medication for type II diabetes, initially entered the spotlight as a
promising anti-cancer agent due to epidemiologic reports that found reduced cancer risk …

The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or
in combination with ionizing radiation were studied with MCF-7 human breast cancer cells …

Ovarian cancer (OvCa) is the fifth most common cause of death from all cancers among
women in United Sates and the leading cause of death from gynecological malignancies …

Studies regarding macroautophagic/autophagic regulation in endothelial cells (ECs) under
diabetic conditions are very limited. Clinical evidence establishes an endothelial protective …