The evolution of neurofilament light chain in multiple sclerosis

C Ferreira-Atuesta, S Reyes, G Giovanonni… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the
central nervous system characterized by demyelination and axonal damage. Diagnosis and …

Synthetic MRI: technologies and applications in neuroradiology

S Ji, D Yang, J Lee, SH Choi, H Kim… - Journal of Magnetic …, 2022 - Wiley Online Library
Synthetic MRI is a technique that synthesizes contrast‐weighted images from multicontrast
MRI data. There have been advances in synthetic MRI since the technique was introduced …

Serum neurofilament light in MS: The first true blood-based biomarker?

S Thebault, G Bose, R Booth… - Multiple Sclerosis …, 2022 - journals.sagepub.com
A simple blood-derived biomarker is desirable in the routine management of multiple
sclerosis (MS) patients and serum neurofilament light chain (sNfL) is the most promising …

Molecular biomarkers and cognitive impairment in multiple sclerosis: state of the field, limitations, and future direction–a systematic review and meta-analysis

TD Rademacher, SG Meuth, H Wiendl, A Johnen… - Neuroscience & …, 2023 - Elsevier
Objective Multiple sclerosis (MS) is associated with cognitive impairment (CI) such as
slowed information processing speed (IPS). Currently, no immunocellular or molecular …

Neurofilaments: the C-reactive protein of neurology

KL Lambertsen, CB Soares, D Gaist, HH Nielsen - Brain sciences, 2020 - mdpi.com
Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of
neurology, suggesting their use as an unspecific screening marker, much like the use of …

Validity of serum neurofilament light chain as a prognostic biomarker of disease activity in multiple sclerosis

MK Sen, MJ Hossain, DA Mahns, BJ Brew - Journal of Neurology, 2023 - Springer
Multiple sclerosis (MS) is a chronic demyelinating and neuroinflammatory disease of the
human central nervous system with complex pathoetiology, heterogeneous presentations …

Emerging biomarkers of multiple sclerosis in the blood and the CSF: a focus on neurofilaments and therapeutic considerations

T Biernacki, Z Kokas, D Sandi, J Füvesi… - International Journal of …, 2022 - mdpi.com
Introduction: Multiple Sclerosis (MS) is the most common immune-mediated chronic
neurodegenerative disease of the central nervous system (CNS) affecting young people …

Serum neurofilament light chain: No clear relation to cognition and neuropsychiatric symptoms in stable MS

O Aktas, A Renner, A Huss, M Filser… - Neurology …, 2020 - AAN Enterprises
Objective To explore the hypothesis that serum neurofilament light chain (sNfL) indicative of
neuroaxonal damage may improve precise disease profiling with regard to cognition and …

[HTML][HTML] Network analysis characterizes key associations between subjective fatigue and specific depressive symptoms in early relapsing-remitting multiple sclerosis

YT Chang, PKA Kearns, A Carson, DC Gillespie… - Multiple Sclerosis and …, 2023 - Elsevier
Background Fatigue is common and disabling in multiple sclerosis (MS), yet its mechanisms
are poorly understood. In particular, overlap in measures of fatigue and depression …

Identifying early neuropsychological indicators of cognitive involvement in multiple sclerosis

ES Gromisch, Z Dhari - Neuropsychiatric disease and treatment, 2021 - Taylor & Francis
Multiple sclerosis (MS) is a debilitating disease of the central nervous system that is most
commonly seen in early to middle adulthood, although it can be diagnosed during childhood …