The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

The global impact, over the last 25 years, of the principles of green chemistry and
sustainability, and the pivotal role of the E factor concept in driving resource efficiency and …

Biocatalysis can empower chemical, pharmaceutical, and energy industries, where the use
of enzymes facilitates low-energy, sustainable methods of producing high-value chemicals …

Over the past ten years, scientific and technological advances have established biocatalysis
as a practical and environmentally friendly alternative to traditional metallo-and …

Pharmaceutical synthesis can benefit greatly from the selectivity gains associated with
enzymatic catalysis. Here, we report an efficient biocatalytic process to replace a recently …

The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …

Herein we present a review on methods for carbonyl reductions on large scale (≥ 100
mmol) applied to the synthesis of drug candidates in the pharmaceutical industry. We …

The use of enzymes as catalysts for the preparation of novel compounds has received
steadily increasing attention over the past few years. High demands are placed on the …

The recent development of a broad range of biocatalysts that can be applied in organic
synthesis has brought into focus the need to rethink the way in which organic target …