Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for
the study of epithelial organ development and evolution. Here, we review the developmental …

Teeth develop as ectodermal appendages from epithelial and mesenchymal tissues. Tooth
organogenesis is regulated by an intricate network of cell–cell signaling during all steps of …

Tooth agenesis or hypodontia, failure to develop all normally developing teeth, is one of the
most common developmental anomalies in man. Common forms, including third molar …

Most characteristics of tooth shape and pattern can be altered by modulating the signal
pathways mediating epithelial–mesenchymal interactions in developing teeth. These …

Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively
little is known about the aetiology and molecular mechanisms underlying supernumerary …

Tooth renewal is initiated from epithelium associated with existing teeth. The development of
new teeth requires dental epithelial cells that have competence for tooth formation, but …

The principles of formation, renewal, and eruption of teeth are discussed. Numerous genetic
aberrations may affect the formation and eruption of teeth. Cleidocranial dysplasia (CCD) …

Mammalian teeth develop from oral ectoderm and neural crest derived mesenchyme. The
first morphological sign is the primary dental lamina forming as a thickening of oral …

Teeth are typical examples of organs in which genes determine the progress of
development from initiation to the final shape, size and structure, whereas environmental …

In past decades, morphologic, molecular, and cellular mechanisms that govern tooth
development have been extensively studied. These studies demonstrated that the same …