Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and
programmed cell death protein 1 (PD1) as negative regulators of antitumour immunity led to …

Impressive advances in defining the properties of receptors for the Fc portion of
immunoglobulins (FcR) have been made over the past several years. Ligand specificities …

Since the description of the first mouse knockout for an IgG Fc receptor seven years ago,
considerable progress has been made in defining the in vivo functions of these receptors in …

Anti-CD20 antibody immunotherapy effectively treats non-Hodgkin's lymphoma and
autoimmune disease. However, the cellular and molecular pathways for B cell depletion …

Multiple functions have recently been identified for the neonatal Fc receptor FcRn. In
addition, a human homolog of the rodent forms of FcRn has been identified and …

IgG immune complexes are of central importance in the humoral immune system and
strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune …

Antibodies can completely suppress or enhance the antibody response to their specific
antigen by several hundredfold. Immunoglobulin M (IgM) enhances antibody responses via …

Although mounting evidence indicates that platelets participate in the modulation of both
innate and adaptive immunity, the mechanisms by which platelets exert these effects have …

Autoimmune diseases, like rheumatoid arthritis, result from a dysregulation of the immune
response culminating in hyperactivation of effector cells leading to immune-mediated injury …