Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Investigation of receptor—ligand interactions remains an inexhaustible challenge for
chemists and biologists. Structural exploration of biological receptors is the starting point for …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

The Cl-secretory pathway that is defective in cystic fibrosis (CF) can be bypassed by an
alternative pathway for Cl-transport that is activated by extracellular nucleotides …

Strong evidence has been provided that ATP can act as a transmitter not only in smooth
muscle but also in peripheral ganglia and in brain. The cloning and molecular identification …

We have investigated responses of human monocyte/macrophage cells to extracellular ATP
(ATPe). Freshly isolated peripheral blood monocytes showed responses linked to P2Y but …

In order to isolate new subtypes of P 2 purinoceptors, sets of degenerate oligonucleotide
primers were synthesized on the basis of the best conserved segments in the published …

The P2Y receptors are a widely expressed group of eight nucleotide-activated G protein-
coupled receptors (GPCRs). The P2Y 1 (ADP), P2Y 2 (ATP/UTP), P2Y 4 (UTP), P2Y 6 …

We have investigated the purinoceptor subtypes responsible for calcium signaling in human
platelets, which previous studies have shown to involve both Ca 2+ influx via receptor …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …