Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …

As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …

Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …

Drug resistance is an important factor for treatment failure of gastric cancer. N6‐
methyladenosine (m6A) is the predominant mRNA internal modification in eukaryotes. The …

Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …

Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …

Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …

Cell death is a necessary event in life and is crucial for the regulation of organismal
development, homeostasis, aging and pathological conditions. There are different modes of …

The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …