[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
[HTML][HTML] Role of non-coding RNAs and RNA modifiers in cancer therapy resistance
X Zhang, K Xie, H Zhou, Y Wu, C Li, Y Liu, Z Liu, Q Xu… - Molecular cancer, 2020 - Springer
As the standard treatments for cancer, chemotherapy and radiotherapy have been widely
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …
applied to clinical practice worldwide. However, the resistance to cancer therapies is a major …
Inhibiting autophagy to prevent drug resistance and improve anti-tumor therapy
Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …
resistance by tumor cells represents a primary obstacle for successful chemotherapy …
[HTML][HTML] Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications
L Zou, M Liao, Y Zhen, S Zhu, X Chen, J Zhang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Abstract UNC-51-like kinase 1 (ULK1), as a serine/threonine kinase, is an autophagic
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
initiator in mammals and a homologous protein of autophagy related protein (Atg) 1 in yeast …
M6A demethylase fat mass and obesity‐associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Y Zhang, L Gao, W Wang, T Zhang, F Dong… - Cancer …, 2022 - Wiley Online Library
Drug resistance is an important factor for treatment failure of gastric cancer. N6‐
methyladenosine (m6A) is the predominant mRNA internal modification in eukaryotes. The …
methyladenosine (m6A) is the predominant mRNA internal modification in eukaryotes. The …
MicroRNA-mediated autophagy regulation in cancer therapy: the role in chemoresistance/chemosensitivity
M Ashrafizadeh, A Zarrabi, S Orouei… - European Journal of …, 2021 - Elsevier
Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …
Now, scientists should consider molecular pathways and mechanisms involved in …
[HTML][HTML] MicroRNAs as major regulators of the autophagy pathway
Y Akkoc, D Gozuacik - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2020 - Elsevier
Autophagy is a cellular stress response mechanism activation of which leads to degradation
of cellular components, including proteins as well as damaged organelles in lysosomes …
of cellular components, including proteins as well as damaged organelles in lysosomes …
Revealing the role of miRNA-489 as a new onco-suppressor factor in different cancers based on pre-clinical and clinical evidence
MDA Paskeh, S Mirzaei, S Orouei, A Zabolian… - International Journal of …, 2021 - Elsevier
Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …
[HTML][HTML] Non-coding RNAs in breast cancer: Implications for programmed cell death
Y Luo, W Tang, S Xiang, J Feng, X Zu - Cancer Letters, 2022 - Elsevier
Cell death is a necessary event in life and is crucial for the regulation of organismal
development, homeostasis, aging and pathological conditions. There are different modes of …
development, homeostasis, aging and pathological conditions. There are different modes of …
[HTML][HTML] A review of ULK1-mediated autophagy in drug resistance of cancer
L Liu, L Yan, N Liao, WQ Wu, JL Shi - Cancers, 2020 - mdpi.com
The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …