Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

M Batie, T Fasanya, NS Kenneth, S Rocha - EMBO reports, 2023 - embopress.org
Oxygen is essential for viability in mammalian organisms. However, cells are often exposed
to changes in oxygen availability, due to either increased demand or reduced oxygen …

[HTML][HTML] Functional crosstalk between chromatin and hypoxia signalling

H Collier, A Albanese, CS Kwok, J Kou, S Rocha - Cellular Signalling, 2023 - Elsevier
Eukaryotic genomes are organised in a structure called chromatin, comprising of DNA and
histone proteins. Chromatin is thus a fundamental regulator of gene expression, as it offers …

Oxygen sensing and transcriptional regulation under hypoxia exposure in the mollusk Crassostrea gigas

J Meng, T Wang, B Li, L Li, G Zhang - Science of The Total Environment, 2022 - Elsevier
Hypoxia caused by global climate change and anthropogenic pollution has exposed marine
species to increasing stress. Oxygen sensing mediated by prolyl hydroxylase (PHD) is …

Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis

TJ Phua - Frontiers in aging, 2023 - frontiersin.org
Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely
associated with human age-related carcinogenesis and chronic diseases. However, the …

Metabolite Analyses Using Nuclear Magnetic Resonance (NMR) Spectroscopy in Plasma of Patients with Prostate Cancer

D Ahmed, S Cacciatore, LF Zerbini - Metabolic Reprogramming: Methods …, 2023 - Springer
Nuclear magnetic resonance (NMR) spectroscopy enables the detection and the
quantification of a large range of molecules, including low-molecular-weight metabolites and …

Fixed Cell Immunofluorescence for Quantification of Hypoxia-Induced Changes in Histone Methylation

D Shakir, M Batie, S Rocha - Metabolic Reprogramming: Methods and …, 2023 - Springer
Hypoxia and its signalling pathway play a key role in human physiology and a variety of
diseases. Alterations in histone methylation coordinate transcriptional responses to hypoxia …

[图书][B] Role of JmjC histone demethylases in hypoxia induced NF-κB response

D Shakir - 2022 - search.proquest.com
Reduced oxygen availability or increased demand for oxygen create an imbalance called
hypoxia, which is an essential condition for regulating many physiological processes such …

Hypoxia research, where to now?

BM Ortmann, CT Taylor, S Rocha - Trends in Biochemical Sciences, 2024 - cell.com
Investigating how cells and organisms sense and respond to O 2 levels is essential to our
understanding of physiology and pathology. This field has advanced considerably since the …