The BRICHOS protein superfamily is a diverse group of proteins associated with a wide
variety of human diseases, including respiratory distress, COVID‐19, dementia, and cancer …

An extracellular network of molecular chaperones protects a diverse array of proteins that
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …

Proteins must fold into three-dimensional structures to execute their biological functions.
Therefore, maintenance of protein homeostasis, proteostasis, including prevention of protein …

Mutations in ITM2B have been reported to be associated with several familial dementias,
such as Familial British dementia and familial Danish dementia. These are autosomal …

Common neuropathologies associated with dementia include Alzheimer's disease
neuropathologic change (ADNC) and limbic-predominant age-related TDP-43 …

Alzheimer's disease (AD) is a multifactorial disorder driven by abnormal amyloid β-peptide
(Aβ) levels. In this study, we investigated the role of presenilin-like signal peptide peptidase …

Aims/hypothesis Repeated exposures to insulin-induced hypoglycaemia in people with
diabetes progressively impairs the counterregulatory response (CRR) that restores …

The neuroscience community has largely accepted the notion that functional neurons can be
generated from neural stem cells in the adult brain, especially in two brain regions: the …

Protein functionality hinges on precise three-dimensional structures, while molecular
chaperones orchestrate folding, proteome maintenance, and proteostasis. Recent attention …

Alzheimer's disease (AD) is a multifactorial disorder driven by abnormal amyloid β-peptide
(Aβ) levels. To identify new druggable pathways involved in the Aβ cascade we here …