Classically, platelets have been described as the cellular blood component that mediates
hemostasis and thrombosis. This important platelet function has received significant …

Platelets are hematopoietic cells whose main function has for a long time been considered
to be the maintenance of vascular integrity. They have an essential role in the hemostatic …

Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease.
However, a number of features suggest alternative mechanisms of platelet destruction. In …

Current understanding of tumor immunosuppressive mechanisms forms the basis for
modern day immunotherapies. Immunoregulatory role of platelets in cancer remains largely …

Platelets are key vascular effectors in hemostasis, with activation signals leading to fast
recruitment, aggregation, and clot formation. The canonical process of hemostasis is well …

Platelets (small, anucleate cell fragments) derive from large precursor cells, megakaryocytes
(MKs), that reside in the bone marrow. MKs emerge from hematopoietic stem cells in a …

血小板在人体内不仅参与止血, 也是重要的免疫细胞, 在维持血管完整性, 炎症,
调节免疫过程和肿瘤发生发展中起着关键作用, 本文总结了血小板发挥免疫调节作用的途径 …

Impairment of vascular integrity is a hallmark of inflammatory diseases. We recently reported
that single immune-responsive platelets migrate and reposition themselves to sites of …

The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are
phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to …

Mild thrombocytopenia, changes in platelet gene expression, enhanced platelet
functionality, and presence of platelet-rich thrombi in the lung have been associated with …