Promoter DNA hypermethylation and paradoxical gene activation
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …
regulation of gene expression. The manner in which DNA methylation contributes to …
DNA methylation readers and cancer: mechanistic and therapeutic applications
N Mahmood, SA Rabbani - Frontiers in oncology, 2019 - frontiersin.org
DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …
causes transcriptional activation or repression of genes in a context-dependent manner. In …
[HTML][HTML] Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines
N Pajuelo-Lozano, S Alcalá, B Sainz Jr, R Perona… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Gastric cancer (GC) is a solid tumor that contains subpopulations of cancer stem
cells (CSCs), which are considered drivers of tumor initiation and metastasis; responsible for …
cells (CSCs), which are considered drivers of tumor initiation and metastasis; responsible for …
Multi-site desmoplastic small round cell tumors are genetically related and immune-cold
CC Wu, HC Beird, SE Lamhamedi-Cherradi… - NPJ precision …, 2022 - nature.com
Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue sarcoma
that is characterized by the EWSR1-WT1 fusion protein. Patients present with hundreds of …
that is characterized by the EWSR1-WT1 fusion protein. Patients present with hundreds of …
[HTML][HTML] Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease
Abstract Wilms' tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during
lung development but is downregulated in postnatal stages and adult lungs. We recently …
lung development but is downregulated in postnatal stages and adult lungs. We recently …
[HTML][HTML] Aberrant expression of ETS1 and ETS2 proteins in cancer
EA Fry, K Inoue - Cancer reports and reviews, 2018 - ncbi.nlm.nih.gov
The ETS transcription factors regulate expression of genes involved in normal cell
development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 …
development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 …
Moonlighting in mitosis: analysis of the mitotic functions of transcription and splicing factors
Moonlighting proteins can perform one or more additional functions besides their primary
role. It has been posited that a protein can acquire a moonlighting function through a …
role. It has been posited that a protein can acquire a moonlighting function through a …
[HTML][HTML] Loss of CBX2 induces genome instability and senescence-associated chromosomal rearrangements
C Baumann, X Zhang, R De La Fuente - The Journal of cell biology, 2020 - ncbi.nlm.nih.gov
The polycomb group protein CBX2 is an important epigenetic reader involved in cell
proliferation and differentiation. While CBX2 overexpression occurs in a wide range of …
proliferation and differentiation. While CBX2 overexpression occurs in a wide range of …
Integrative multi-OMICs identifies therapeutic response biomarkers and confirms fidelity of clinically annotated, serially passaged patient-derived xenografts …
PH Pandya, AJ Jannu, K Bijangi-Vishehsaraei… - Cancers, 2022 - mdpi.com
Simple Summary Solid tumors account for~ 60% of pediatric, as well as adolescent and
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL
GOL Rodrigues, SD Cramer, HY Winer… - Advances in Biological …, 2021 - Elsevier
The IL-7 pathway is required for normal T cell development and survival. In recent years the
pathway has been shown to be a major driver of acute lymphoblastic leukemia (ALL), the …
pathway has been shown to be a major driver of acute lymphoblastic leukemia (ALL), the …