DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …

DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …

Rationale: Gastric cancer (GC) is a solid tumor that contains subpopulations of cancer stem
cells (CSCs), which are considered drivers of tumor initiation and metastasis; responsible for …

Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue sarcoma
that is characterized by the EWSR1-WT1 fusion protein. Patients present with hundreds of …

Abstract Wilms' tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during
lung development but is downregulated in postnatal stages and adult lungs. We recently …

The ETS transcription factors regulate expression of genes involved in normal cell
development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 …

Moonlighting proteins can perform one or more additional functions besides their primary
role. It has been posited that a protein can acquire a moonlighting function through a …

The polycomb group protein CBX2 is an important epigenetic reader involved in cell
proliferation and differentiation. While CBX2 overexpression occurs in a wide range of …

Simple Summary Solid tumors account for~ 60% of pediatric, as well as adolescent and
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …

The IL-7 pathway is required for normal T cell development and survival. In recent years the
pathway has been shown to be a major driver of acute lymphoblastic leukemia (ALL), the …