c-Rel is a member of the nuclear factor κB (NF-κB) transcription factor family. Unlike other NF-
κB proteins that are expressed in a variety of cell types, high levels of c-Rel expression are …

NF-κB is activated by many stimuli and NF-κB binding sites have been identified in a wide
variety of genes. Yet, NF-κB-dependent gene expression must be stimulus-and cell-type …

Abstract Rationale: Breast cancer (BrCa) is the most common cancer worldwide, and the 5-
year relative survival rate has declined in patients diagnosed at stage IV. Advanced BrCa is …

Regulatory T (Treg) cells maintain immune homeostasis and prevent inflammatory and
autoimmune responses. During development, thymocytes bearing a moderately self-reactive …

The Th17 cells use the retinoid-related orphan receptor-γ (Rorg or Rorc) to specify their
differentiation and lineage-specific function. However, how Rorg is switched on during Th17 …

We conducted a genome-wide association study of rheumatoid arthritis in 2,418 cases and
4,504 controls from North America and identified an association at the REL locus, encoding …

Basaloid skin tumors, including basal cell carcinoma (BCC) and basaloid follicular
hamartoma, are associated with aberrant Hedgehog (Hh) signaling and, in the case of BCC …

Purpose Bilberries are abundant in polyphenols. Dietary polyphenols have been associated
with strategies for prevention and treatment of chronic inflammatory diseases. We …

During thymopoiesis, a unique program of gene expression promotes the development of
CD4 regulatory T (T reg) cells. Although Foxp3 maintains a pattern of gene expression …

The transcription factor nuclear factor κB (NF-κB) rapidly reprograms gene expression in
response to various stimuli, and its activity is regulated by several posttranslational …