Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

Behavioral researchers have increasingly become interested in the idea that chronic, low-
grade inflammation is a pathway through which social and behavioral variables exert long …

British Psychology Society Textbook of the Year 2020 Why do people who are more socially
connected live longer and have better health than those who are socially isolated? Why are …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of
nervous systems in both invertebrates and vertebrates. It has been proposed for several …

We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

Alterations in brain intrinsic activity—as organized in resting-state networks (RSNs) such as
sensorimotor network (SMN), salience network (SN), and default-mode network (DMN) …

The serotonin hypothesis of depression has played an important role in the history of
psychiatry, yet it has also been criticized for the delayed onset and inadequate efficacy of …

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …