Fullerenes and related carbon based derivatives have shown a growing relevance in
biology and medicine, mainly due to the unique electronic and structural properties that …

Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated
from birch trees, but present in many other botanical sources. It is found in different plant …

Since the emergence of HIV and AIDS in the early 1980s, the development of safe and
effective therapies has accompanied a massive increase in our understanding of the …

Human immunodeficiency virus-1 capsid (HIV-1 CA) is involved in different stages of the
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …

HIV-1 protease (PR) cleavage of the Gag polyprotein triggers the assembly of mature,
infectious particles. Final cleavage of Gag occurs at the junction helix between the capsid …

This review comprehensively describes the recent advances in the synthesis and
pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins …

The human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)
epidemic is one of the world's most serious health challenges. Although combination …

Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag
via an orchestrated series of proteolytic cleavage events. A longstanding question concerns …

Combined HIV antiretroviral therapy (cART) has been effective except if drug resistance
emerges. As cART has been rolled out in low-income countries, drug resistance has …

ABSTRACT BMS-955176 is a second-generation human immunodeficiency virus type 1
(HIV-1) maturation inhibitor (MI). A first-generation MI, bevirimat, showed clinical efficacy in …