Chromatin structure and gene expression are dynamically controlled by post-translational
modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation …

The DNA damage response factor 53BP1 functions at the intersection of two major double
strand break (DSB) repair pathways–promoting nonhomologous end-joining (NHEJ) and …

We demonstrate that the androgen receptor (AR) regulates a transcriptional program of DNA
repair genes that promotes prostate cancer radioresistance, providing a potential …

How chromatin shapes pathways that promote genome–epigenome integrity in response to
DNA damage is an issue of crucial importance. We report that human bromodomain (BRD) …

Chromosomal double strand breaks provoke an extensive reaction in neighboring
chromatin, characterized by phosphorylation of histone H2AX on serine 139 of its C-terminal …

A timely and accurate cellular response to DNA damage requires tight regulation of the
action of DNA damage response (DDR) proteins at lesions. A multitude of posttranslational …

Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage.
Here, we highlight a new cross talk between chronic oxidative stress and the histone variant …

Genetic information is recorded in specific DNA sequences that must be protected to
preserve normal cellular function. Genome maintenance pathways have evolved to sense …

One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …