KATP Channels in the Cardiovascular System

MN Foster, WA Coetzee - Physiological reviews, 2016 - journals.physiology.org
KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Muscle KATP Channels: Recent Insights to Energy Sensing and Myoprotection

TP Flagg, D Enkvetchakul, JC Koster… - Physiological …, 2010 - journals.physiology.org
ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

DA Brown, AJ Chicco, KN Jew… - The Journal of …, 2005 - Wiley Online Library
This study was conducted to examine the role of myocardial ATP‐sensitive potassium
(KATP) channels in exercise‐induced protection from ischaemia–reperfusion (I–R) injury …

The Sulfonylurea Receptor, an Atypical ATP-Binding Cassette Protein, and Its Regulation of the KATP Channel

MA Burke, RK Mutharasan, H Ardehali - Circulation research, 2008 - Am Heart Assoc
ATP-binding cassette (ABC) proteins are highly conserved and widely expressed throughout
nature and found in all organisms, both prokaryotic and eukaryotic. They mediate myriad …

[PDF][PDF] Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia

F Kolář, B Ošťádal - Physiol Res, 2004 - biomed.cas.cz
Effective protection of the heart against ischemia/reperfusion injury is one of the most
important goals of experimental and clinical research in cardiology. Besides ischemic …

Cardiac adaptation to chronic high-altitude hypoxia: beneficial and adverse effects

B Ostadal, F Kolar - Respiratory physiology & neurobiology, 2007 - Elsevier
This review deals with the capability of the heart to adapt to chronic hypoxia in animals
exposed to either natural or simulated high altitude. From the broad spectrum of related …

Upregulation of ATP-sensitive potassium channels as the potential mechanism of cardioprotection and vasorelaxation under the action of pyridoxal-5-phosphate in old …

RB Strutynskyi, NA Strutynska… - Journal of …, 2023 - journals.sagepub.com
Background: The aging process is accompanied by the weakening of the protective systems
of the organism, in particular by the decrease in the expression of ATP-sensitive potassium …

AMP‐activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP‐sensitive K+ channels

A Sukhodub, S Jovanović, Q Du… - Journal of cellular …, 2007 - Wiley Online Library
Brief periods of ischemia and reperfusion that precede sustained ischemia lead to a
reduction in myocardial infarct size. This phenomenon, known as ischemic preconditioning …

The citrus flavanone Naringenin protects myocardial cells against age‐associated damage

E Da Pozzo, B Costa, C Cavallini… - Oxidative Medicine …, 2017 - Wiley Online Library
In recent years, the health‐promoting effects of the citrus flavanone naringenin have been
examined. The results have provided evidence for the modulation of some key mechanisms …

Novel role of silent information regulator 1 in myocardial ischemia

Y Yang, W Duan, Y Li, Z Jin, J Yan, S Yu, D Yi - Circulation, 2013 - Am Heart Assoc
Yang et al SIRT1 in Myocardial Ischemia 2233 starvation, hypoxia, endoplasmic reticulum
stress, and oxidative stress. 11 Autophagy is progressively activated in mice after 3 days of …