Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
Murine models of sepsis and trauma: can we bridge the gap?
Sepsis and trauma are both leading causes of death in the United States and represent
major public health challenges. Murine models have largely been used in sepsis and …
major public health challenges. Murine models have largely been used in sepsis and …
[HTML][HTML] Mouse models of ageing and their relevance to disease
Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …
different biological pathways, and the underlying cellular mechanisms are complex. In view …
Abandon the mouse research ship? Not just yet!
Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-
driven research in mice. The underlying premise posits that mice sufficiently emulate …
driven research in mice. The underlying premise posits that mice sufficiently emulate …
Local hemostasis, immunothrombosis, and systemic disseminated intravascular coagulation in trauma and traumatic shock
S Gando, Y Otomo - Critical care, 2015 - Springer
Knowing the pathophysiology of trauma-induced coagulopathy is important for the
management of severely injured trauma patients. The aims of this review are to provide a …
management of severely injured trauma patients. The aims of this review are to provide a …
The future of murine sepsis and trauma research models
Recent comparisons of the murine and human transcriptome in health and disease have
called into question the appropriateness of the use of murine models for human sepsis and …
called into question the appropriateness of the use of murine models for human sepsis and …
Update on the definition of polytrauma
NE Butcher, ZJ Balogh - European Journal of Trauma and Emergency …, 2014 - Springer
Purpose The definition and use of the term “polytrauma” is inconsistent and lacks validation.
This article describes the historical evolution of the term and geographical differences in its …
This article describes the historical evolution of the term and geographical differences in its …
The quest for a universal definition of polytrauma: a trauma registry-based validation study
NE Butcher, C D'Este, ZJ Balogh - Journal of trauma and acute …, 2014 - journals.lww.com
BACKGROUND A pilot validation recommended defining polytrauma as patients with an
Abbreviated Injury Scale (AIS) score greater than 2 in at least two Injury Severity Score (ISS) …
Abbreviated Injury Scale (AIS) score greater than 2 in at least two Injury Severity Score (ISS) …
A detailed characterization of the dysfunctional immunity and abnormal myelopoiesis induced by severe shock and trauma in the aged
DC Nacionales, B Szpila, R Ungaro… - The Journal of …, 2015 - journals.aai.org
The elderly are particularly susceptible to trauma, and their outcomes are frequently dismal.
Such patients often have complicated clinical courses and ultimately die of infection and …
Such patients often have complicated clinical courses and ultimately die of infection and …
[HTML][HTML] The effects of biological sex on sepsis treatments in animal models: a systematic review and a narrative elaboration on sex-and gender-dependent differences …
OBJECTIVES: Preclinical studies provide an opportunity to evaluate the relationship
between sex and sepsis, and investigate underlying mechanisms in a controlled …
between sex and sepsis, and investigate underlying mechanisms in a controlled …