[HTML][HTML] Oxidative stress-based therapeutics in COPD

PJ Barnes - Redox biology, 2020 - Elsevier
Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease

F Maltais, M Decramer, R Casaburi… - American journal of …, 2014 - atsjournals.org
Background: Limb muscle dysfunction is prevalent in chronic obstructive pulmonary disease
(COPD) and it has important clinical implications, such as reduced exercise tolerance …

Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999‐2002

W Zhang, SF Peng, L Chen, HM Chen… - Oxidative medicine …, 2022 - Wiley Online Library
Purpose. Leukocyte telomere length (LTL) is an important biomarker of aging. The oxidative
balance score (OBS) is used to assess the oxidative stress‐related exposures of diet and …

The involvement of the oxidative stress status in cancer pathology: a double view on the role of the antioxidants

KF Zahra, R Lefter, A Ali, EC Abdellah… - Oxidative Medicine …, 2021 - Wiley Online Library
Oxygen‐free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS),
are known by their “double‐sided” nature in biological systems. The beneficial effects of …

Oxidative stress in COPD

PA Kirkham, PJ Barnes - Chest, 2013 - Elsevier
Oxidative stress is now recognized as a major predisposing factor in the pathogenesis of
COPD. Existing therapies for COPD are ineffective at halting disease progression, with …

Systematic analysis of the aberrances and functional implications of ferroptosis in cancer

Z Liu, Q Zhao, ZX Zuo, SQ Yuan, K Yu, Q Zhang… - Iscience, 2020 - cell.com
Ferroptosis is a type of cell death related to cancer; however, the characteristics of
ferroptosis in cancers are still uncertain. Based on the data in The Cancer Genome Atlas, we …

COPD and stroke: are systemic inflammation and oxidative stress the missing links?

V Austin, PJ Crack, S Bozinovski, AA Miller… - Clinical …, 2016 - portlandpress.com
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation and loss of lung function, and is currently the third largest cause of death in the …

Quadriceps wasting and physical inactivity in patients with COPD

D Shrikrishna, M Patel, RJ Tanner… - European …, 2012 - Eur Respiratory Soc
Quadriceps weakness is an important complication of advanced chronic obstructive
pulmonary disease (COPD) but few data exist concerning muscle bulk in early disease. We …

[HTML][HTML] Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings

J Gea, S Pascual, C Casadevall… - Journal of thoracic …, 2015 - ncbi.nlm.nih.gov
Respiratory and/or limb muscle dysfunction, which are frequently observed in chronic
obstructive pulmonary disease (COPD) patients, contribute to their disease prognosis …

Dynamic changes in intracellular ROS levels regulate airway basal stem cell homeostasis through Nrf2-dependent Notch signaling

MK Paul, B Bisht, DO Darmawan, R Chiou, VL Ha… - Cell stem cell, 2014 - cell.com
Airways are exposed to myriad environmental and damaging agents such as reactive
oxygen species (ROS), which also have physiological roles as signaling molecules that …