Immunotherapies have emerged as one of the most promising approaches to treat patients
with cancer. Recently, there have been many clinical successes using checkpoint receptor …

Abstract Background The Network for Pancreatic Organ Donors with Diabetes (nPOD) was
established to recover and characterize pancreata and related organs from cadaveric organ …

Objective The objective of the current study was to compare the responses to different ex
vivo immunogenic challenges between immune cells derived from metabolically healthy …

Psoriasis is linked to systemic inflammation and cardiovascular comorbidities, but studies of
the underlying cellular mechanisms are lacking. The NLRP3 inflammasome is genetically …

Routine techniques for the isolation of human peripheral blood mononuclear cells (PBMCs)
include density centrifugation with Ficoll-Paque and isolation by cell preparation tubes …

Chronic fatigue syndrome (CFS) is a highly debilitating disease of unknown aetiology.
Abnormalities in bioenergetic function have been cited as one possible cause for CFS …

The concept of regulatory T cell (Treg)-based immunotherapy has enormous potential for
facilitating tolerance in autoimmunity and transplantation. Clinical translation of Treg cell …

The increasing number of diabetes individuals in the globe has alarmed the medical sector
to seek alternatives to improve their medical technologies. Machine learning and deep …

Background & Aims Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease
usually requiring life-long immunosuppression. The mechanisms for disease initiation and …

Pharmaceutical investigators are searching for preclinical models closely resembling the
original cancer and predicting clinical outcome. This study compares drug response of three …