Eukaryotic genomes are organized into condensed, heterogeneous chromatin fibers
throughout much of the cell cycle. Here we describe recent studies indicating that even …

Covalent modifications of the histone proteins have well-known roles in gene expression.
Experiments reported during the past year have extended this paradigm to include roles for …

The RNA genome of the human T-cell leukemia virus type 1 (HTLV-1) codes for proteins
involved in infectivity, replication, and transformation. We report in this study the …

Transcriptional coactivators that modify histones represent an increasingly important group
of regulatory factors, although their ability to modify other factors as well precludes common …

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

Recent structures of the nucleosome core particle reveal details of histone–histone and
histone–DNA interactions. These structures have now set the stage for understanding …

H2A. Bbd is an unusual histone variant whose sequence is only 48% conserved compared
to major H2A. The major sequence differences are in the docking domain that tethers the …

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription
from the viral promoter via association with the cellular basic leucine zipper factor cAMP …

The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several
proteins that are unique to the virus within its 3′-end region. Among them, the viral …

Activation of human T cell leukemia virus type 1 (HTLV-1) transcription is established
through the formation of protein complexes on the viral promoter that are essentially …