Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders
sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance …

Although horses with asthma share similar clinical signs, the heterogeneity of the disease in
terms of severity, triggering factors, inflammatory profile, and pathological features has …

Background Airway inflammation and airway hyperresponsiveness (AHR) are pivotal
characteristics of equine asthma. Lipopolysaccharide (LPS) may have a central role in …

Equine asthma (EA) is a heterogenous, complex disease, with a significant negative impact
on horse welfare and performance. EA and human asthma share fundamental similarities …

A state-of-the-art multi-omics approach was applied to improve our understanding of the
aetio-pathogenesis of a highly prevalent, performance-limiting disorder of racehorses: mild …

Extracellular vesicles (EVs) contribute to intercellular communication through the transfer of
their rich cargo to recipient cells. The EVs produced by LPS-stimulated neutrophils from …

Neutrophilic airway inflammation is highly prevalent in racehorses in training, with the term
mild to moderate equine asthma (MMEA) being applied to the majority of such cases. Our …

Background Studies in people have found neutrophil gelatinase‐associated lipocalin
(NGAL) concentrations are increased in asthma and can be used to distinguish between …

Equine asthma (EA) is a respiratory syndrome associated with the increase of different
leukocyte populations in the bronchoalveolar lavage fluid (BALF). Its pathogenetic …

Advancements in DNA sequencing over the past decade have transformed our ability to
characterize genetic variation in large populations and study the genetics of many complex …