Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Current developments in LC-MS for pharmaceutical analysis

M Beccaria, D Cabooter - Analyst, 2020 - pubs.rsc.org
Liquid chromatography (LC) based techniques in combination with mass spectrometry (MS)
detection have had a large impact on the development of new pharmaceuticals in the past …

Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples

JMT Wong, PA Malec, OS Mabrouk, J Ro, M Dus… - … of Chromatography A, 2016 - Elsevier
Widely targeted metabolomic assays are useful because they provide quantitative data on
large groups of related compounds. We report a high performance liquid chromatography …

Adverse effects polystyrene microplastics exert on zebrafish heart–Molecular to individual level

A Dimitriadi, C Papaefthimiou, E Genizegkini… - Journal of Hazardous …, 2021 - Elsevier
In the present study the effects of sublethal concentrations of polystyrene microplastics (PS-
MPs) on zebrafish were evaluated at multiple levels, related to fish activity and oxidative …

Toxicity and functional tissue responses of two freshwater fish after exposure to polystyrene microplastics

M Kaloyianni, DC Bobori, D Xanthopoulou, G Malioufa… - Toxics, 2021 - mdpi.com
Microplastics (MPs)'ingestion has been demonstrated in several aquatic organisms. This
process may facilitate the hydrophobic waterborne pollutants or chemical additives transfer …

Development of a liquid chromatography–high resolution mass spectrometry metabolomics method with high specificity for metabolite identification using all ion …

S Naz, H Gallart-Ayala, SN Reinke, C Mathon… - Analytical …, 2017 - ACS Publications
High-resolution mass spectrometry (HRMS)-based metabolomics approaches have made
significant advances. However, metabolite identification is still a major challenge with …

[图书][B] Liquid chromatography: applications

S Fanali, PR Haddad, C Poole, ML Riekkola - 2017 - books.google.com
Liquid Chromatography: Applications, Second Edition, is a single source of authoritative
information on all aspects of the practice of modern liquid chromatography. It gives those …

Hyphenated MS-based targeted approaches in metabolomics

O Begou, HG Gika, ID Wilson, G Theodoridis - Analyst, 2017 - pubs.rsc.org
While global metabolic profiling (untargeted metabolomics) has been the center of much
interest and research activity in the past few decades, more recently targeted metabolomics …

Comprehensive targeted metabolomic assay for urine analysis

J Zheng, L Zhang, M Johnson, R Mandal… - Analytical …, 2020 - ACS Publications
Among all the human biological fluids used for disease biomarker discovery or clinical
chemistry, urine stands out. It can be collected easily and noninvasively, it is readily …

Hydrophilic interaction chromatography for the analysis of biopharmaceutical drugs and therapeutic peptides: A review based on the separation characteristics of the …

T Ikegami - Journal of separation science, 2019 - Wiley Online Library
Applications of hydrophilic interaction chromatography for the analysis of biopharmaceutical
drugs, ie, glycosylated proteins represented by monoclonal antibodies are discussed in the …