The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Spatial and temporal diversity of glycome expression in mammalian brain

J Lee, S Ha, M Kim, SW Kim, J Yun… - Proceedings of the …, 2020 - National Acad Sciences
Mammalian brain glycome remains a relatively poorly understood area compared to other
large-scale “omics” studies, such as genomics and transcriptomics due to the inherent …

High-mannose glycans are elevated during breast cancer progression

MLA De Leoz, LJT Young, HJ An… - Molecular & Cellular …, 2011 - ASBMB
Alteration in glycosylation has been observed in cancer. However, monitoring glycosylation
changes during breast cancer progression is difficult in humans. In this study, we used a well …

Glycomics and disease markers

HJ An, SR Kronewitter, MLA de Leoz… - Current opinion in …, 2009 - Elsevier
Glycomics is the comprehensive study of all glycans expressed in biological systems. The
biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl …

Studying Lactoferrin N-Glycosylation

S Karav, JB German, C Rouquié, A Le Parc… - International journal of …, 2017 - mdpi.com
Lactoferrin is a multifunctional glycoprotein found in the milk of most mammals. In addition to
its well-known role of binding iron, lactoferrin carries many important biological functions …

Comprehensive structural glycomic characterization of the glycocalyxes of cells and tissues

Q Li, Y Xie, M Wong, M Barboza, CB Lebrilla - Nature Protocols, 2020 - nature.com
The glycocalyx comprises glycosylated proteins and lipids and fcorms the outermost layer of
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …

A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

JR Wang, WN Gao, R Grimm, S Jiang, Y Liang… - Nature …, 2017 - nature.com
N-linked glycans on immunoglobulin G (IgG) have been associated with pathogenesis of
diseases and the therapeutic functions of antibody-based drugs; however, low-abundance …

Developments in the identification of glycan biomarkers for the detection of cancer

LR Ruhaak, S Miyamoto, CB Lebrilla - Molecular & Cellular Proteomics, 2013 - ASBMB
Changes in glycosylation readily occur in cancer and other disease states. Thanks to recent
advances in the development of analytical techniques and instrumentation, especially in …

pGlycoQuant with a deep residual network for quantitative glycoproteomics at intact glycopeptide level

S Kong, P Gong, WF Zeng, B Jiang, X Hou… - Nature …, 2022 - nature.com
Large-scale intact glycopeptide identification has been advanced by software tools.
However, tools for quantitative analysis remain lagging behind, which hinders exploring the …