The DNA damage response to transcription stress
The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …
A unified model for the G1/S cell cycle transition
Efficient S phase entry is essential for development, tissue repair, and immune defences.
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …
However, hyperactive or expedited S phase entry causes replication stress, DNA damage …
DNA–protein crosslink proteases in genome stability
A Ruggiano, K Ramadan - Communications Biology, 2021 - nature.com
Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …
Isolation and detection of DNA–protein crosslinks in mammalian cells
I Torrecilla, A Ruggiano, K Kiianitsa… - Nucleic Acids …, 2024 - academic.oup.com
DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …
Emerging applications of cold plasma technology in cereal grains and products
Background The use of cold plasma technology (CPT) in the food industry could be a
promising alternative to heat treatment techniques in practice. The CPT is effective in …
promising alternative to heat treatment techniques in practice. The CPT is effective in …
FAM111A protects replication forks from protein obstacles via its trypsin-like domain
Y Kojima, Y Machida, S Palani, TR Caulfield… - Nature …, 2020 - nature.com
Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …
tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the …
TEX264 coordinates p97-and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Abstract Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …
DNA replication and transcription. TOP1 is also a major driver of endogenous genome …
Debulking of topoisomerase DNA-protein crosslinks (TOP-DPC) by the proteasome, non-proteasomal and non-proteolytic pathways
Topoisomerases play a pivotal role in ensuring DNA metabolisms during replication,
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …
transcription and chromosomal segregation. To manage DNA topology, topoisomerases …
Entrenching role of cell cycle checkpoints and autophagy for maintenance of genomic integrity
Genomic integrity of the cell is crucial for the successful transmission of genetic information
to the offspring and its survival. Persistent DNA damage induced by endogenous and …
to the offspring and its survival. Persistent DNA damage induced by endogenous and …
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability
DNA-protein crosslinks (DPCs) are a specific type of DNA lesion in which proteins are
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …
covalently attached to DNA. Unrepaired DPCs lead to genomic instability, cancer …