Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Acute kidney injury (AKI) and cardiorenal syndrome (CRS) are increasingly prevalent in
hospitalized patients with cardiovascular disease and remain associated with poor short …

Introduction Several novel beta-lactams (BLs) and/or beta lactams/beta-lactamase inhibitors
(BL/BLIs) have been recently developed for the management of multidrug-resistant bacterial …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Antibiotic dosing in critically ill patients undergoing continuous renal replacement therapy is
considered challenging. This study aimed to analyse the population pharmacokinetics of …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is now a global outbreak of disease. The antiviral …

Abstract Linezolid, vancomycin, teicoplanin, tigecycline, imipenem, meropenem,
voriconazole, and micafungin are eight special-grade antimicrobials commonly used for …

Purpose: Antibiotics are frequently used in patients receiving intermittent or continuous renal
replacement therapy (RRT). Continuous renal replacement may alter the pharmacokinetics …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …