Low back pain (LBP), as a leading cause of disability, is a common musculoskeletal disorder
that results in major social and economic burdens. Recent research has identified …

Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect
organisms against various noxious stimuli including DNA damage, oxidative stress …

Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies
low back pain. Overloading-induced cell death, especially endogenous stem cell death, is …

Mechanical stimulation plays a crucial part in the development of intervertebral disc
degeneration (IDD). Extracellular matrix (ECM) stiffness, which is a crucial mechanical …

Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major
social and economic burdens; however, its underlying molecular mechanisms remain poorly …

Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP)
cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells …

Intervertebral disc degeneration (IDD), characterized as decreased proteoglycan content,
ossification of endplate, and decreased intervertebral height, is one of the major reasons of …

Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of
low back pain (LBP), which causes an enormous socioeconomic burden. Previous studies …

Low back pain (LBP) is a chronic condition that can affect up to 80% of the global
population. It is the number one cause of disability worldwide and has enormous …

Mechanical loading of the intervertebral disc (IVD) initiates cell‐mediated remodeling events
that contribute to disc degeneration. Cells of the IVD, nucleus pulposus (NP) and anulus …