The signal pathways and treatment of cytokine storm in COVID-19
L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …
and is more devastating than any other previous infectious disease. It has affected a …
The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options
S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …
now become a serious health issue to mankind. Activation of inflammatory signaling …
[HTML][HTML] Proinflammatory cytokines levels in sepsis and healthy volunteers, and tumor necrosis factor-alpha associated sepsis mortality: A systematic review and meta …
AA Gharamti, O Samara, A Monzon, G Montalbano… - Cytokine, 2022 - Elsevier
Background Sepsis is a global health challenge associated with significant morbidity and
mortality. Detrimental sepsis effects are attributed to excessive inflammation or a “cytokine …
mortality. Detrimental sepsis effects are attributed to excessive inflammation or a “cytokine …
Cytokine storm-calming property of the isoquinoline alkaloids in Coptis chinensis Franch
Y Lan, H Wang, J Wu, X Meng - Frontiers in Pharmacology, 2022 - frontiersin.org
Coronavirus disease (COVID-19) has spread worldwide and its effects have been more
devastating than any other infectious disease. Importantly, patients with severe COVID-19 …
devastating than any other infectious disease. Importantly, patients with severe COVID-19 …
Aptamers for proteins associated with rheumatic diseases: progress, challenges, and prospects of diagnostic and therapeutic applications
EA Shatunova, MA Korolev, VO Omelchenko… - Biomedicines, 2020 - mdpi.com
Nucleic acid aptamers capable of affine and specific binding to their molecular targets have
now established themselves as a very promising alternative to monoclonal antibodies for …
now established themselves as a very promising alternative to monoclonal antibodies for …
[HTML][HTML] HMGB1 mediates acute liver injury in sepsis through pyroptosis of liver macrophages
Y Huang, K Zang, F Shang, S Guo, L Gao… - International Journal of …, 2020 - ncbi.nlm.nih.gov
Sepsis is a systemic inflammatory response syndrome caused by infection. Septic patients
often show an acute liver dysfunction during the onset of sepsis in ICU. We found the levels …
often show an acute liver dysfunction during the onset of sepsis in ICU. We found the levels …
Repurposing simvastatin for treatment of Klebsiella pneumoniae infections: in vitro and in vivo study
Simvastatin had minimum inhibitory concentrations of 32 to 128 µg/mL against Klebsiella
pneumoniae isolates and hindered the biofilm-formation ability of 58.54% of the isolates. It …
pneumoniae isolates and hindered the biofilm-formation ability of 58.54% of the isolates. It …
Punicalagin suppresses inflammation in ventilator‐induced lung injury through protease‐activated receptor‐2 inhibition‐induced inhibition of NLR family pyrin domain …
W Zhang, Q Zhu - Chemical Biology & Drug Design, 2022 - Wiley Online Library
Punicalagin is recorded to be a potent anti‐inflammatory drug, while its effect on
inflammation existing in ventilator‐induced lung injury (VILI) requires further verification …
inflammation existing in ventilator‐induced lung injury (VILI) requires further verification …
Variants in TNF and NOS3 (eNOS) genes associated with sepsis in adult patients
M Özkan, N Günay, EF Sener… - The journal of gene …, 2021 - Wiley Online Library
Background Sepsis is a life‐threatening condition caused by a dysregulated host response
to infections and is a leading cause of death in hospitalized patients. The present study …
to infections and is a leading cause of death in hospitalized patients. The present study …
脓毒症基因多态性的研究新进展
蔡敏杰, 金莹莹, 林荣海, 徐颖鹤, 陈琪, 蒋永泼 - 中华全科医学, 2021 - zhqkyx.net
脓毒症(sepsis) 是感染引起宿主反应失调导致的危及生命的器官功能障碍,
是临床危重症患者死亡的主要原因之一. 最新研究表示脓毒症发病率每年以1.5%~ 9.0 …
是临床危重症患者死亡的主要原因之一. 最新研究表示脓毒症发病率每年以1.5%~ 9.0 …