Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

Peroxisomes are highly metabolic, autonomously replicating organelles that generate
reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells …

Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

This article is part of a Minifocus on Ubiquitin. For further reading, please see related
articles: ʻUbiquitin and SUMO in DNA repair at a glanceʼ by Helle D. Ulrich (J. Cell Sci …

Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same
time, these organelles generate reactive oxygen and nitrogen species as byproducts …