Graded exercise testing (GXT) is the most widely used assessment to examine the dynamic
relationship between exercise and integrated physiological systems. The information from …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The objective of this book remains the same as that stated in the first edition: to present a
comprehensive perspective of biomechanics from the stand point of bioengineering …

The beating heart possesses intrinsic ability to adapt cardiac output to changes in
mechanical load. The century-old Frank-Starling law and Anrep effect have documented that …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

The vascular myogenic response refers to the acute reaction of a blood vessel to a change
in transmural pressure. This response is critically important for the development of resting …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

The passive tension-sarcomere length relation of rat cardiac muscle was investigated by
studying passive (or not activated) single myocytes and trabeculae. The contribution of …

Tissue engineers and stem cell biologists have made exciting progress toward creating
simplified models of human heart muscles or aligned monolayers to help bridge a …