The tumor microenvironment (TME), including intracellular and extracellular
microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen …

Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …

Lung carcinoma is one of the most common cancers and has one of the lowest survival rates
in the world. Cytokines such as interleukin-12 (IL-12) have demonstrated considerable …

Ionizable cationic lipids are recognized as an essential component of lipid nanoparticles
(LNPs) for messenger RNA (mRNA) delivery but can be confounded by low lipoplex stability …

Immunotherapy has revolutionized oncology remarkably and gained great improvements in
cancer therapy. However, tumor immunotherapy still encounters serious challenges …

The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …

Nanomedicines overcome the pharmacokinetic limitations of traditional drug formulations
and have promising prospect in cancer treatment. However, nanomedicine delivery in vivo is …

Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort
has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics …

Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …

Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly
or under non‐physiological conditions, thereby limiting their biomedical, environmental, and …