Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential

X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Amino acid metabolism in health and disease

ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers

OO Coker, C Liu, WKK Wu, SH Wong, W Jia, JJY Sung… - Microbiome, 2022 - Springer
Background Gut microbiota contributes to colorectal cancer (CRC) pathogenesis through
microbes and their metabolites. The importance of microbiota-associated metabolites in …

Amino acid depletion therapies: starving cancer cells to death

M Butler, LT van der Meer, FN van Leeuwen - Trends in Endocrinology & …, 2021 - cell.com
Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …

Branched-chain amino acids: catabolism in skeletal muscle and implications for muscle and whole-body metabolism

G Mann, S Mora, G Madu, OAJ Adegoke - Frontiers in Physiology, 2021 - frontiersin.org
Branched-chain amino acids (BCAAs) are critical for skeletal muscle and whole-body
anabolism and energy homeostasis. They also serve as signaling molecules, for example …

Lysine catabolism reprograms tumour immunity through histone crotonylation

H Yuan, X Wu, Q Wu, A Chatoff, E Megill, J Gao… - Nature, 2023 - nature.com
Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore

M Zhang, C Tang, Z Wang, S Chen, D Zhang, K Li… - Nature …, 2024 - nature.com
Precise identification and quantification of amino acids is crucial for many biological
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …

Electrocatalytic Systems for NOx Valorization in Organonitrogen Synthesis

P Liao, J Kang, R Xiang, S Wang, G Li - Angewandte Chemie, 2024 - Wiley Online Library
Inorganic nitrogen oxide (NOx) species, such as NO, NO2, NO3−, NO2− generated from the
decomposition of organic matters, volcanic eruptions and lightning activated nitrogen, play …

Iron-containing protein-mimic supramolecular iron delivery systems for ferroptosis tumor therapy

S Liu, M Zhang, H Jin, Z Wang, Y Liu… - Journal of the …, 2022 - ACS Publications
Ferroptosis provides an innovative theoretical basis and method for tumor therapy but is
limited by the low efficiency of conventional iron delivery systems. Herein, an efficient …

Advancing cancer treatment by targeting glutamine metabolism—A roadmap

A Halama, K Suhre - Cancers, 2022 - mdpi.com
Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …