Metabolic reprogramming and epigenetic modifications in cancer: from the impacts and mechanisms to the treatment potential
X Xu, Q Peng, X Jiang, S Tan, Y Yang… - … & Molecular Medicine, 2023 - nature.com
Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …
Amino acid metabolism in health and disease
ZN Ling, YF Jiang, JN Ru, JH Lu, B Ding… - Signal Transduction and …, 2023 - nature.com
Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …
Altered gut metabolites and microbiota interactions are implicated in colorectal carcinogenesis and can be non-invasive diagnostic biomarkers
Background Gut microbiota contributes to colorectal cancer (CRC) pathogenesis through
microbes and their metabolites. The importance of microbiota-associated metabolites in …
microbes and their metabolites. The importance of microbiota-associated metabolites in …
Amino acid depletion therapies: starving cancer cells to death
M Butler, LT van der Meer, FN van Leeuwen - Trends in Endocrinology & …, 2021 - cell.com
Targeting tumor cell metabolism is an attractive form of therapy, as it may enhance treatment
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …
response in therapy resistant cancers as well as mitigate treatment-related toxicities by …
Branched-chain amino acids: catabolism in skeletal muscle and implications for muscle and whole-body metabolism
G Mann, S Mora, G Madu, OAJ Adegoke - Frontiers in Physiology, 2021 - frontiersin.org
Branched-chain amino acids (BCAAs) are critical for skeletal muscle and whole-body
anabolism and energy homeostasis. They also serve as signaling molecules, for example …
anabolism and energy homeostasis. They also serve as signaling molecules, for example …
Lysine catabolism reprograms tumour immunity through histone crotonylation
Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …
Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore
Precise identification and quantification of amino acids is crucial for many biological
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …
applications. Here we report a copper (II)-functionalized Mycobacterium smegmatis porin A …
Electrocatalytic Systems for NOx Valorization in Organonitrogen Synthesis
P Liao, J Kang, R Xiang, S Wang, G Li - Angewandte Chemie, 2024 - Wiley Online Library
Inorganic nitrogen oxide (NOx) species, such as NO, NO2, NO3−, NO2− generated from the
decomposition of organic matters, volcanic eruptions and lightning activated nitrogen, play …
decomposition of organic matters, volcanic eruptions and lightning activated nitrogen, play …
Iron-containing protein-mimic supramolecular iron delivery systems for ferroptosis tumor therapy
S Liu, M Zhang, H Jin, Z Wang, Y Liu… - Journal of the …, 2022 - ACS Publications
Ferroptosis provides an innovative theoretical basis and method for tumor therapy but is
limited by the low efficiency of conventional iron delivery systems. Herein, an efficient …
limited by the low efficiency of conventional iron delivery systems. Herein, an efficient …
Advancing cancer treatment by targeting glutamine metabolism—A roadmap
Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …