Food allergy

H Renz, KJ Allen, SH Sicherer, HA Sampson… - Nature reviews Disease …, 2018 - nature.com
Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Targeting eosinophils in allergy, inflammation and beyond

PC Fulkerson, ME Rothenberg - Nature reviews Drug discovery, 2013 - nature.com
Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

[HTML][HTML] Anti–Siglec-8 antibody for eosinophilic gastritis and duodenitis

ES Dellon, KA Peterson, JA Murray… - … England Journal of …, 2020 - Mass Medical Soc
Background Eosinophilic gastritis and duodenitis are characterized by gastrointestinal
mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate …

Single-cell RNA sequencing of mast cells in eosinophilic esophagitis reveals heterogeneity, local proliferation, and activation that persists in remission

NBB Morgenstern, AY Ballaban, T Wen, T Shoda… - Journal of Allergy and …, 2022 - Elsevier
Background Mast cells (MCs) are pleiotropic cells that accumulate in the esophagus of
patients with eosinophilic esophagitis (EoE) and are thought to contribute to disease …

Intravenous anti–IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis

ME Rothenberg, T Wen, A Greenberg, O Alpan… - Journal of Allergy and …, 2015 - Elsevier
Background Eosinophilic esophagitis (EoE) is a chronic allergic disease with limited
treatment options. Objective We evaluated QAX576, an mAb against IL-13, in the treatment …

Management guidelines of eosinophilic esophagitis in childhood

A Papadopoulou, S Koletzko… - Journal of pediatric …, 2014 - journals.lww.com
Objectives: Eosinophilic esophagitis (EoE) represents a chronic, immune/antigen-mediated
esophageal disease characterized clinically by symptoms related to esophageal dysfunction …

Joint ESPGHAN/NASPGHAN guidelines on childhood eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis

A Papadopoulou, J Amil‐Dias… - Journal of pediatric …, 2024 - Wiley Online Library
Introduction Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis (non‐
EoE EGIDs) are rare chronic inflammatory disorders of the gastrointestinal (GI) tract …

[HTML][HTML] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious …

KL Winthrop, X Mariette, JT Silva, E Benamu… - Clinical Microbiology …, 2018 - Elsevier
Background The present review is part of the ESCMID Study Group for Infections in
Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and …

The use of biologics in food allergy

A Fiocchi, BP Vickery, RA Wood - Clinical & Experimental …, 2021 - Wiley Online Library
Background Food allergy continues to pose problems due to its increased frequency and its
increasingly high severity. In this context, alongside the traditional avoidance strategies of …

Eosinophilic gastroenteritis: diagnosis and clinical perspectives

T Sunkara, P Rawla, KS Yarlagadda… - Clinical and …, 2019 - Taylor & Francis
Eosinophilic gastroenteritis (EGE) is a digestive disorder in children and adults that is
characterized by eosinophilic infiltration in the stomach and intestine. The underlying …