Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely
related to focal adhesion kinase (FAK), which plays an important role in sensing cell …

Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …

Increasing evidence indicates that a key factor in neurodegenerative diseases is the
activation of the unfolded protein response (UPR) caused by an accumulation of misfolded …

Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence
showing that increased lamin B1 levels contribute to the pathophysiology of Huntington's …

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder
characterized by the loss of motor control and cognitive ability, which eventually leads to …

STriatal-Enriched protein tyrosine Phosphatase (STEP) is a tyrosine phosphatase that has
been implicated in Alzheimer's disease (AD), the most common form of dementia, and many …

The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be
classified into striosome, also known as patch, and matrix, based on neurochemical …

Protein tyrosine phosphatases, together with protein tyrosine kinases, control many
molecular signaling steps that control life at cellular and organismal levels. Impairing …

The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and
STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) …

We recently demonstrated that a tonic activation of adenosine A2A receptors (A2ARs) is
required for cocaine‐induced synaptic depression and increase in the activity of STriatal …