Cytokines are indispensable signals of the mucosa-associated immune system for
maintaining normal gut homeostasis. An imbalance of their profile in favour of inflammation …

Animal models of intestinal inflammation are indispensable for our understanding of the
pathogenesis of Crohn disease and Ulcerative colitis, the idiopathic forms of inflammatory …

Background & Aims: Interleukin-12 and interleukin-23 are inflammatory cytokines implicated
in Crohn's disease pathophysiology. Ustekinumab is a monoclonal antibody against the p40 …

Cytokines play an important role in the immunopathogenesis of inflammatory bowel disease
(IBD), including Crohn's disease and ulcerative colitis, where they drive and regulate …

Background Ustekinumab is a monoclonal antibody targeting interleukins‐12 and‐23, with
efficacy in Crohn's disease (CD) demonstrated in clinical trials. Aim To assess the real‐world …

Background Ustekinumab is a fully human monoclonal antibody against IL-12/23.
Ustekinumab induced clinical response and maintained higher rate of response than …

Background: It is unclear whether psychological stress contributes to the inflammatory
process in the inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's …

Depression is one of the leading mental illnesses worldwide and lowers the quality of life of
many. According to WHO, about 5% of the worldwide population suffers from depression …

Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disorder
characterized by the loss of tolerance to self-antigens and dysregulated interferon …

尽管对溃疡性结肠炎的临床研究有100 多年的历史, 但是他的真正病因尚不清楚,
多种因素可能促进这种疾病的发生和发展. 环境因素可能影响遗传易感性, 遗传易感性与异常的 …