Recurrent topics in mass spectrometry-based metabolomics and lipidomics—standardization, coverage, and throughput

E Rampler, YE Abiead, H Schoeny, M Rusz… - Analytical …, 2020 - ACS Publications
We have come a long way in the last years of developing analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

[HTML][HTML] Ceramides and ceramide synthases in cancer: Focus on apoptosis and autophagy

J Alizadeh, SC da Silva Rosa, X Weng, J Jacobs… - European Journal of …, 2023 - Elsevier
Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Lipidomic profiling of human serum enables detection of pancreatic cancer

D Wolrab, R Jirásko, E Cífková, M Höring, D Mei… - Nature …, 2022 - nature.com
Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body
fluids may improve the survival time prognosis of patients, who are often diagnosed too late …

A super-resolution strategy for mass spectrometry imaging via transfer learning

T Liao, Z Ren, Z Chai, M Yuan, C Miao, J Li… - Nature Machine …, 2023 - nature.com
High-spatial-resolution mass spectrometry imaging (HSR-MSI) provides precise spatial
information on thousands of biomolecules without labelling across a tissue section. Deep …

Validation of lipidomic analysis of human plasma and serum by supercritical fluid chromatography–mass spectrometry and hydrophilic interaction liquid …

D Wolrab, M Chocholoušková, R Jirásko… - Analytical and …, 2020 - Springer
Ultrahigh-performance supercritical fluid chromatography–mass spectrometry
(UHPSFC/MS) has a great potential for the high-throughput lipidomic quantitation of …

Reprogrammed lipid metabolism and the lipid-associated hallmarks of colorectal cancer

T Salita, YH Rustam, D Mouradov, OM Sieber, GE Reid - Cancers, 2022 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third-most diagnosed cancer and the
second-leading cause of cancer-related deaths worldwide. Limitations in early and accurate …

Ultrahigh-performance supercritical fluid chromatography/mass spectrometry in the lipidomic analysis

D Wolrab, O Peterka, M Chocholoušková… - TrAC Trends in …, 2022 - Elsevier
Ultrahigh-performance supercritical fluid chromatography/mass spectrometry (UHPSFC/MS)
is one of the fastest analytical approaches for high-throughput lipidomic analysis covering a …

Plasma lipidomic profiles of kidney, breast and prostate cancer patients differ from healthy controls

D Wolrab, R Jirásko, O Peterka, J Idkowiak… - Scientific Reports, 2021 - nature.com
Early detection of cancer is one of the unmet needs in clinical medicine. Peripheral blood
analysis is a preferred method for efficient population screening, because blood collection is …

Lipidomic characterization of exosomes isolated from human plasma using various mass spectrometry techniques

O Peterka, R Jirásko, M Chocholoušková… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Ultrahigh-performance supercritical fluid chromatography-mass spectrometry
(UHPSFC/MS), ultrahigh-performance liquid chromatography-mass spectrometry …

Retention dependences support highly confident identification of lipid species in human plasma by reversed-phase UHPLC/MS

Z Vaňková, O Peterka, M Chocholoušková… - Analytical and …, 2022 - Springer
Reversed-phase ultrahigh-performance liquid chromatography-mass spectrometry (RP-
UHPLC/MS) method was developed with the aim to unambiguously identify a large number …