Pharmacology of acid-sensing ion channels–Physiological and therapeutical perspectives
A Baron, E Lingueglia - Neuropharmacology, 2015 - Elsevier
Abstract Development of the pharmacology of Acid-Sensing Ion Channels (ASICs) has
become a key challenge to study their structure, their molecular and cellular functions and …
become a key challenge to study their structure, their molecular and cellular functions and …
Acid‐sensing ion channels as potential therapeutic targets in neurodegeneration and neuroinflammation
Acid‐sensing ion channels (ASICs) are a family of proton‐sensing channels that are voltage
insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by …
insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by …
The role of acid sensing ion channels in the cardiovascular function
O López-Ramírez, A González-Garrido - Frontiers in Physiology, 2023 - frontiersin.org
Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and
pathophysiological functions including synaptic plasticity, sensory systems and nociception …
pathophysiological functions including synaptic plasticity, sensory systems and nociception …
Interactive role of acid sensing ion channels and glutamatergic system in opioid dependence
F Alasmari, DB Sari, H Alhaddad, SS Al-Rejaie… - Neuroscience & …, 2022 - Elsevier
Dysregulation in glutamatergic receptors and transporters has been found to mediate drugs
of abuse, including morphine. Among glutamate receptors, ionotropic glutamate receptors …
of abuse, including morphine. Among glutamate receptors, ionotropic glutamate receptors …
Symbiotic bacterial communities in ants are modified by invasion pathway bottlenecks and alter host behavior
Biological invasions are a threat to global biodiversity and provide unique opportunities to
study ecological processes. Population bottlenecks are a common feature of biological …
study ecological processes. Population bottlenecks are a common feature of biological …
The role of acid-sensing ion channel 3 in the modulation of tooth mechanical hyperalgesia induced by orthodontic tooth movement
H Yang, D Shan, Y Jin, H Liang, L Liu, Y Guan, C Chen… - Neuroscience, 2020 - Elsevier
This study aimed to explore the role of acid-sensing ion channel 3 (ASIC3) in the modulation
of tooth mechanical hyperalgesia induced by orthodontic tooth movement. In male Sprague …
of tooth mechanical hyperalgesia induced by orthodontic tooth movement. In male Sprague …
The anti-nociceptive potential of tulathromycin against chemically and thermally induced pain in mice
The present study was conducted to evaluate the analgesic potential of the new triamilide
macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously …
macrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneously …
Multiple regulatory actions of 2-guanidine-4-methylquinazoline (GMQ), an agonist of acid-sensing ion channel type 3, on ionic currents in pituitary GH3 cells and in …
EC So, Y Wang, LQ Yang, KH So, YC Lo… - Biochemical …, 2018 - Elsevier
Abstract GMQ (2-guanidine-4-methylquinazoline or N-(4-methyl-2-quinazolinyl)-guanidine
hydrochloride), an agonist of acid-sensing ion channel type 3, has been increasingly used …
hydrochloride), an agonist of acid-sensing ion channel type 3, has been increasingly used …
Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain
WA Prado, AC Rossaneis, I Carvalho… - Journal of Pharmacy …, 2015 - academic.oup.com
Objectives To assess the antinociceptive activity of the neomycin derivatives neamine and 2-
deoxystreptamine following intraspinal administration in rats. Methods We used the tail-flick …
deoxystreptamine following intraspinal administration in rats. Methods We used the tail-flick …
Rational design and synthesis of small molecules targeted against neurodegenerative processes and diseases
D Gornati - 2019 - air.unimi.it
Improved sanitary conditions, disease prevention (eg, vaccinations) and treatment (eg,
antibiotics) have increased life expectancy, up to the 67.2 years value in 2010 …
antibiotics) have increased life expectancy, up to the 67.2 years value in 2010 …