As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

Glucose homeostasis, regulated by glucose-dependent insulinotropic polypeptide (GIP),
glucagon-like peptide-1 (GLP-1) and glucagon (GCG) is critical to human health. Several …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Class B1 G protein-coupled receptors (GPCRs) play important roles in human physiology
and disease pathology. Using cryo-electron microscopy (cryo-EM) and X-ray …

The intestine represents the body's largest interface between internal organs and external
environments except for its nutrient and fluid absorption functions. It has the ability to sense …

The classical paradigm of G protein-coupled receptor (GPCR) signaling via G proteins is
grounded in a view that downstream responses are relatively transient and confined to the …

Bradykinin and kallidin are endogenous kinin peptide hormones that belong to the kallikrein–
kinin system and are essential to the regulation of blood pressure, inflammation, coagulation …

G protein-coupled receptors (GPCRs) are the largest class of cell surface drug targets.
Advances in stabilization of GPCR: transducer complexes, together with improvements in …

The intestinal hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-
like peptide-2 (GLP-2) are key regulators of postprandial bone turnover in humans. We …