Recent methodology progress of deep learning for RNA–protein interaction prediction

X Pan, Y Yang, CQ Xia, AH Mirza… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
Interactions between RNAs and proteins play essential roles in many important biological
processes. Benefitting from the advances of next generation sequencing technologies …

A systematic benchmark of machine learning methods for protein–RNA interaction prediction

M Horlacher, G Cantini, J Hesse… - Briefings in …, 2023 - academic.oup.com
RNA-binding proteins (RBPs) are central actors of RNA post-transcriptional regulation.
Experiments to profile-binding sites of RBPs in vivo are limited to transcripts expressed in …

Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures

L Sun, K Xu, W Huang, YT Yang, P Li, L Tang, T Xiong… - Cell research, 2021 - nature.com
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …

Global importance analysis: An interpretability method to quantify importance of genomic features in deep neural networks

PK Koo, A Majdandzic, M Ploenzke… - PLoS computational …, 2021 - journals.plos.org
Deep neural networks have demonstrated improved performance at predicting the
sequence specificities of DNA-and RNA-binding proteins compared to previous methods …

[HTML][HTML] Multi-feature fusion for deep learning to predict plant lncRNA-protein interaction

JS Wekesa, J Meng, Y Luan - Genomics, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) play key roles in regulating cellular biological processes
through diverse molecular mechanisms including binding to RNA binding proteins. The …

A deep learning model for plant lncRNA-protein interaction prediction with graph attention

JS Wekesa, J Meng, Y Luan - Molecular Genetics and Genomics, 2020 - Springer
Long non-coding RNAs (lncRNAs) play a broad spectrum of distinctive regulatory roles
through interactions with proteins. However, only a few plant lncRNAs have been …

[HTML][HTML] Incorporating biological structure into machine learning models in biomedicine

J Crawford, CS Greene - Current opinion in biotechnology, 2020 - Elsevier
In biomedical applications of machine learning, relevant information often has a rich
structure that is not easily encoded as real-valued predictors. Examples of such data include …

RNA-binding protein recognition based on multi-view deep feature and multi-label learning

H Yang, Z Deng, X Pan, HB Shen… - Briefings in …, 2021 - academic.oup.com
RNA-binding protein (RBP) is a class of proteins that bind to and accompany RNAs in
regulating biological processes. An RBP may have multiple target RNAs, and its aberrant …

Integrating thermodynamic and sequence contexts improves protein-RNA binding prediction

Y Su, Y Luo, X Zhao, Y Liu, J Peng - PLoS computational biology, 2019 - journals.plos.org
Predicting RNA-binding protein (RBP) specificity is important for understanding gene
expression regulation and RNA-mediated enzymatic processes. It is widely believed that …

Identifying regulatory elements via deep learning

M Barshai, E Tripto, Y Orenstein - Annual Review of Biomedical …, 2020 - annualreviews.org
Deep neural networks have been revolutionizing the field of machine learning for the past
several years. They have been applied with great success in many domains of the …