Degenerative disc disease is a leading cause of chronic back pain in the aging population in
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …

BACKGROUND CONTEXT: Degeneration and injuries of the intervertebral disc (IVD) result
in large alterations in biomechanical behaviors. Repair strategies using biomaterials can be …

Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

Lumbar discectomy is the surgical procedure most frequently performed for patients
suffering from low back pain and sciatica. Disc herniation as a consequence of degenerative …

Background Intervertebral disc degeneration (IDD) is a major contributor to lower back pain,
however, the molecular and pathogenetic mechanisms underlying IDD are poorly …

This study examines the effect of TNFα on whole bovine intervertebral discs in organ culture
and its association with changes characteristic of intervertebral disc degeneration (IDD) in …

An injectable hydrogel, acting as a reservoir for cell delivery and mimicking the native
environment, offers promise for nucleus pulposus (NP) repair and regeneration. Herein, the …

In recent decades the application of bioreactors has revolutionized the concept of culturing
tissues and organs that require mechanical loading. In intervertebral disc (IVD) research …

Annulus fibrosus (AF) defects from annular tears, herniation, and discectomy procedures are
associated with painful conditions and accelerated intervertebral disc (IVD) degeneration …

BACKGROUND: Much is known about intervertebral disc degeneration, but little effort has
been made to relate this information to the clinical problem of discogenic back pain, and …