Replication fork stalling in late S-phase elicits nascent strand degradation by DNA mismatch repair
E Colicino-Murbach, C Hathaway… - Nucleic Acids …, 2024 - academic.oup.com
Eukaryotic chromosomal replication occurs in a segmented, temporal manner wherein open
euchromatin and compact heterochromatin replicate during early and late S-phase …
euchromatin and compact heterochromatin replicate during early and late S-phase …
RADX prevents genome instability by confining replication fork reversal to stalled forks
RAD51 facilitates replication fork reversal and protects reversed forks from nuclease
degradation. Although potentially a useful replication stress response mechanism …
degradation. Although potentially a useful replication stress response mechanism …
SMC5/6 promotes replication Fork Stability via negative regulation of the COP9 signalosome
MJ Xu, PW Jordan - International journal of molecular sciences, 2024 - mdpi.com
It is widely accepted that DNA replication fork stalling is a common occurrence during cell
proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is …
proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is …
Identification of replication fork-associated proteins in Drosophila embryos and cultured cells using iPOND coupled to quantitative mass spectrometry
Replication of the eukaryotic genome requires the formation of thousands of replication forks
that must work in concert to accurately replicate the genetic and epigenetic information …
that must work in concert to accurately replicate the genetic and epigenetic information …
DCAF14 regulates CDT2 to promote SET8-dependent replication fork protection
N Tirado-Class, C Hathaway, A Nelligan… - Life Science …, 2024 - life-science-alliance.org
DDB1-and CUL4-associated factors (DCAFs) CDT2 and DCAF14 are substrate receptors for
Cullin4–RING E3 ubiquitin ligase (CRL4) complexes. CDT2 is responsible for PCNA …
Cullin4–RING E3 ubiquitin ligase (CRL4) complexes. CDT2 is responsible for PCNA …
RepID represses megakaryocytic differentiation by recruiting CRL4A-JARID1A at DAB2 promoter
JH Jo, JU Park, YM Kim, SM Ok, DK Kim… - Cell Communication and …, 2023 - Springer
Abstract Background Megakaryocytes (MKs) are platelet precursors, which arise from
hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are …
hematopoietic stem cells (HSCs). While MK lineage commitment and differentiation are …
A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer
MAJ Morgan, IK Popova, A Vaidya… - Genes & …, 2021 - genesdev.cshlp.org
Mutations in the PHIP/BRWD2 chromatin regulator cause the human neurodevelopmental
disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to …
disorder Chung-Jansen syndrome, while alterations in PHIP expression are linked to …
PHIP variants associated with Chung–Jansen syndrome disrupt replication fork stability and genome integrity
N Tirado-Class, C Hathaway… - Molecular …, 2022 - molecularcasestudies.cshlp.org
Chung–Jansen syndrome (CJS) is a rare, autosomal dominant disorder characterized by
developmental delay, intellectual disability/cognitive impairment, behavioral challenges …
developmental delay, intellectual disability/cognitive impairment, behavioral challenges …
The detection of a strong episignature for Chung–Jansen syndrome, partially overlapping with Börjeson–Forssman–Lehmann and White–Kernohan syndromes
N Vos, S Haghshenas, L van der Laan, PKM Russel… - Human Genetics, 2024 - Springer
Chung-Jansen syndrome is a neurodevelopmental disorder characterized by intellectual
disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic …
disability, behavioral problems, obesity and dysmorphic features. It is caused by pathogenic …
[HTML][HTML] Pathogenic PHIP variants are variably associated with CAKUT
J de Fallois, T Sieckmann, R Schönauer… - Kidney International …, 2024 - Elsevier
Introduction Congenital anomalies of the kidney and urinary tract (CAKUT) represent the
most common cause of chronic kidney disease in children. While only 20% of cases can be …
most common cause of chronic kidney disease in children. While only 20% of cases can be …